Formulation and Evaluation of Flexible Liposome Embedded In Situ Thermoreversible Intranasal Gel of Rizatriptan Benzoate

The present study deals with formulation and evaluation of flexible liposome embedded thermoreversible in situ intranasal gel rizatriptan benzoate. liposomes were formulated (F1-F9) optimized respect to percentage ethanol phospholipid get optimum vesicle size entrapment efficiency. vesicles characterized for their size, shape zeta potential. stable incorporated into gel. ex vivo permeation drug through goat nasal mucosa was studied. used experiment subjected histopathological check any damages. pharmacokinetic carried out Wistar rats. Vesicles efficiency formulations (F2-F6) varied from 71.2±14.16 199.3±26.03 nm 72.98 % 77.44 respectively. nearly spherical potential -14.2±4.48 -11.7±5.26 mV. improved higher flux across enhancement ratio 2.75 observed liposomal F2 compared normal hydrogel drug. revealed that there no damage epithelial layer found be intact. area under the curve (F2) 3.98 1.53 times more than oral solution respectively, confirming improvement bioavailability. Thus concludes enriched thermoreversible, mucoadhesive benzoate is a safe effective delivery system treatment migraine.